What is Dementia in Pick's disease
Dementia – a syndrome of chronic or progressive brain disease in which are violated higher cortical functions including memory, thinking, orientation, comprehension, counting, learning ability, language and propositions. Consciousness is not darkened. Symptoms are present for at least 6 months, though perhaps is possible a more progressive onset of dementia. Dementia promote long medications, vitamin B12 and B6, a metabolic imbalance due to kidney and liver diseases, and endocrine pathology, vascular pathology, depression, infections, head injuries, alcoholism, cancer. In the diagnosis of dementia also are noted the additional symptoms such as delusions, hallucinations and depression.
WHAT CAUSES DEMENTIA IN PICK’S DISEASE
The disease is associated with atrophic processes in the frontal divisions, most dominant hemisphere, although is also possible steam frontal atrophy. The disease is transmitted most often by the dominant type, although is also described as recessive forms of transmission. Atrophy is caused by gliosis (argyrophilic balls), while is also probable amyloid deposits that resemble Glennera cells. Atrophy leads to an increase in the anterior horns of the ventricles of the brain, compensatory hydrocephalus. Atrophy of the genetically is determined and transmitted by recessive manner. Theory of Pick’s disease similar is to Alzheimer’s disease, although less developed. There is evidence that in the area is marked atrophy of excess zinc.
Prevalence
Affects patients aged over 60 years, although some inappropriate behavior by external harmful factors such as alcohol at a younger age can be explained by provoking presymptoms of the disease.
SYMPTOMS OF DEMENTIA IN PICK’S DISEASE The disease occurs in three stages, initial symptoms are not known. Disease duration is of 10 years.
In the first stage are marked symptoms of social dysfunction and symptoms of unmotivated actions. As their increase is noticeable explicit frontal syndrome. These include: the sharpening of the orientation of the egoistic personality with disinhibition of instincts, which are not controlled. The desire for immediate implementation of instinct leads to the fact that individual actions appear to be lightweight and not motivated by the previous orientation of the individual and not in conformity with the social environment. Patients may have sexual disinhibition, to meet the physiological needs without regard to time and place. It increases the importance of rigid behaviors and kind of conservatism. In a speech there is the symptom of gramophone record, in which patients tell the same secrets, jokes, stories. Emotional life is characterized by unproductive euphoria (Moria) or apathy. With an increase in frontal symptoms are accompanied by apathy or Moriah longer periods, and instinctive disinhibition constant, the so-called spontaneous “field” behavior. Amnestic disorders is not present, their misbehavior patients with relief explain and motivate the “intemperance” or impatience. In some cases, frustration in Pikovsky dementia at the first stage resembles hebephrenia. At the front is dominated by atrophy of the basal emotional and personality disorders, disinhibition and stiffness change each other. In the right-hemisphere localization of anosognosia misconduct is combined with euphoria and complacency in the left-hemispheric localization – with depression. In atrophy of the frontal convexital misconduct is combined with apathy and abulia.
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